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What You Should Know

• The Launch: President Trump has officially launched TrumpRx.gov, a consumer-facing digital portal that allows patients to access “Most-Favored-Nation” (MFN) pricing on high-cost drugs. The initial rollout features deals with five major manufacturers: AstraZeneca, Eli Lilly, EMD Serono, Novo Nordisk, and Pfizer.
• The Prices: The platform delivers massive price cuts on blockbuster GLP-1 weight loss and diabetes drugs. Ozempic and Wegovy will drop from over $1,000/month to as low as $199, while Zepbound will fall to as low as $299.
• The Scope: Beyond weight loss, the initiative targets fertility and chronic care. Patients can save over $2,000 per cycle on fertility meds like Gonal-F, while insulin prices are capped at $25/month and inhalers like Airsupra see prices slashed by over 60%.

GLP-1 Disruption

The launch is anchored by agreements with five pharmaceutical giants: AstraZeneca, Eli Lilly, EMD Serono, Novo Nordisk, and Pfizer.

The most immediate market impact will be felt in the GLP-1 sector (weight loss and diabetes). These drugs have become the most sought-after medications in the country, often costing patients upwards of $1,300 per month out-of-pocket. TrumpRx.gov effectively resets this market:

• Ozempic & Wegovy (Novo Nordisk): Monthly prices will plummet from ~$1,028–$1,349 to an average of $350, with some dosages as low as $199.
• Zepbound (Eli Lilly): The popular weight loss shot will drop from ~$1,088 to an average of $346, reaching as low as $299.

This pricing shift moves these drugs from “luxury goods” to accessible treatments for millions of Americans, potentially disrupting the insurance industry’s current restrictive coverage models.

Beyond Weight Loss: Fertility and Respiratory Care

While GLP-1s will drive the headlines, the platform’s impact on family planning is statistically significant. Fertility treatments are notoriously expensive and often uncovered by insurance.

• Gonal-F: One of the most common fertility injectables will drop to as low as $168 per pen.
• Cetrotide: Will drop from $316 to $22.50.
• Ovidrel: Will fall from $251 to $84.

The administration estimates this could save families over $2,000 per IVF cycle, a massive reduction in the financial barrier to parenthood. Additionally, the portal includes deep discounts on daily essentials for chronic conditions, including Insulin Lispro ($25/month) and COPD inhalers like Bevespi Aerosphere (dropping from $458 to $51).

The Mechanism: “Most-Favored-Nation”

The pricing structure is the result of a series of aggressive policy moves, starting with a May 2025 Executive Order. The administration’s strategy relies on the MFN concept—forcing manufacturers to offer U.S. patients the same price they offer countries with socialized medicine.